The Mental Health Benefits of Anandamide
While anandamide bestows a wealth of overall health benefits, mostly it is linked to mental health and well-being.
Suboptimal levels of anandamide can drain you of happiness, increase fear and anxiety, and rob you of the ability to cope with stress.
The endocannabinoid system, which includes anandamide, offers protection against stress-related psychiatric diseases, including major depression, generalized anxiety, and post-traumatic stress disorder.
Research indicates that inhibiting fatty acid amide hydrolase (FAAH), an enzyme that breaks down anandamide, may be a useful strategy to treat cogntive dysfunction, anxiety disorders, traumatic stress, and drug addiction.
Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide. We previously reported that an elevation of anandamide levels in cerebrospinal fluid inversely correlated to psychotic symptoms.
Furthermore, enhanced anandamide signaling let to a lower transition rate from initial prodromal states into frank psychosis as well as postponed transition. In our translational approach, we performed a double-blind, randomized clinical trial of cannabidiol vs amisulpride, a potent antipsychotic, in acute schizophrenia to evaluate the clinical relevance of our initial findings. Either treatment was safe and led to significant clinical improvement, but cannabidiol displayed a markedly superior side-effect profile.
Moreover, cannabidiol treatment was accompanied by a significant increase in serum anandamide levels, which was significantly associated with clinical improvement. The results suggest that inhibition of anandamide deactivation may contribute to the antipsychotic effects of cannabidiol potentially representing a completely new mechanism in the treatment of schizophrenia.